Meropenem has been reported to be excreted in human milk. 2019 Nov 19;2019:1368397. doi: 10.1155/2019/1368397. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. The pharmacology of meropenem, a new carbapenem antibiotic. Therapeutic uses, prescribing information and product availability may vary between countries. Demographic data are included in Table is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. The dose was 2000 mg every 8 h for all patients, except for those with adverse drug effects or renal impairment (creatinine clearance [CrCL] ≤50 ml/minute), for whom the dose was reduced to 1000 mg every 8 h at the discretion of the attending … Meropenem. eCollection 2019 Jun. Clin Infect Dis. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Meropenem (Meropenem Hikma®; Hikma Pharma, Gräfelfing, Germany) was administered as a prolonged infusion over 4 h using a syringe pump. Along with its needed effects, meropenem may cause some unwanted effects.  |  Last updated on Jul 26, 2020. Byrne S, Maddison J, Connor P, Doughty I, Dodd M, Jenney M, Webb AK, David TJ "Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. Hamacher J, Vogel F, Lichey J, Kohl FV, Diwok K, Wendel H, Lode H "Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis. HHS Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. Animal ages ranged from 0 to 19 years of age, with a median of 11 years. Meropenem resists the actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives. Get the latest research from NIH: https://www.nih.gov/coronavirus. The median age of dogs was 10 years (range, 1‐14), and the median age of cats was 13 years (range, 0‐19). doi: 10.1093/clinids/7.supplement_3.s447. Cependant, certains patients, parents et soignants sont formés pour administrer MEROPENEM MYLAN 1 g, poudre … Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). 2018 Jul 1;73(7):1908-1916. doi: 10.1093/jac/dky128. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. eCollection 2019. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Merrem IV; Descriptions. PLoS Comput Biol. COVID-19 is an emerging, rapidly evolving situation. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. Vomiting Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." Diarrhea 4. Therefore, unlike imipenem, meropenem can be used without dehydropeptidase inhibitors to obtain a consistently high concentration in the urine without nephrotoxic effects. In case of any doubt consult your doctor or pharmacist. Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males. This is especially important if your pet is currently taking probenecid. [Ref], Common (1% to 10%): Peripheral vascular disorder, Uncommon (0.1% to 1%): Heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, bradycardia, hypotension[Ref], Common (1% to 10%): Increased transaminases, Uncommon (0.1% to 1%): Increased AST, increased ALT, increased bilirubin, hepatic failure, cholestatic jaundice/jaundice[Ref], Common (1% to 10%): Hypoglycemia, increased alkaline phosphatase, increased lactate dehydrogenase, Uncommon (0.1% to 1%): Anorexia, hypervolemia, hypokalemia[Ref], Uncommon (0.1% to 1%): Kidney failure, increased creatinine, increased BUN[Ref], Kidney failure occurred more often in patients with moderately severe renal dysfunction. Read the side effects of Meropenem as described in the medical literature. J01DH02 - meropenem ; Belongs to the class of carbapenems. Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children. Baldwin CM, Lyseng-Williamson KA, Keam SJ "Meropenem : a review of its use in the treatment of serious bacterial infections." Clin Infect Dis 24 ( Suppl (1997): s222-30, 9. Satisfied Customers: 7,210. The urinary recovery of meropenem is as high as that of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase. USA.gov. You may report side effects to Health Canada at 1-866-234-2345. It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. Cerner Multum, Inc. "UK Summary of Product Characteristics." Meropenem. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. 1997 Feb;24 Suppl 2:S266-75. CPT Pharmacometrics Syst Pharmacol. 1995 Jul;50(1):73-101. doi: 10.2165/00003495-199550010-00007. Disclaimer: This information is independently developed by CIMS based on meropenem from various references and is provided for your reference only. Meropenem reduces plasma valproate concentrations, affording two mechanisms for an increased risk of seizures in patients with epilepsy, epileptogenic effect of meropenem, and loss of antiepileptic action of valproate [46A,47A,48A,49A,50A,51A,52c]. Verscheijden LFM, Koenderink JB, de Wildt SN, Russel FGM. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. O 0, 3. A Skin Rash 2. Clin Infect Dis 36 (2003): E149-E151. It is the same drug class as Imipenem. These side effects may go away during treatment as your body adjusts to the medicine. Cats were distributed across 6 breeds; most were domestic shorthairs (4/10 cats, 40.0%). has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. 1985 Jul-Aug;7 Suppl 3:S447-51. Medically reviewed by Drugs.com. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. doi: 10.1093/clinids/24.supplement_2.s266. Side effects not requiring immediate medical attention. General Description: Meropenem.  |  Epub 2016 Aug 27. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Eur J Drug Metab Pharmacokinet. Three dogs were excluded from the age count because of an unknown birth date. Meropenem Injectable is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. Storage of the Drug. [Ref], Common (1% to 10%): Pain, inflammation, sepsis/septicemia, shock, accidental injury, Uncommon (0.1% to 1%): Chest pain, fever, back pain, chills, pelvic pain, peripheral edema, abdominal enlargement[Ref], Common (1% to 10%): Inflammation at the injection site, phlebitis/thrombophlebitis, pain at the injection site, Uncommon (0.1% to 1%): Injection site reactions, edema at the injection site[Ref], Common (1% to 10%): Rash (including diaper/nappy area moniliasis), pruritus, Uncommon (0.1% to 1%): Urticaria, sweating, skin ulcer, Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme, severe skin reactions[Ref], Common (1% to 10%): Apnea, pharyngitis, pneumonia, Uncommon (0.1% to 1%): Respiratory disorder, dyspnea, pleural effusion, asthma, increased cough, hypoxia, lung edema, Frequency not reported: Respiratory failure[Ref], Heart failure occurred more often in patients with moderately severe renal dysfunction. Clin Ther 28 (2006): 1164-74, 6. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. We comply with the HONcode standard for trustworthy health information -, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels. 2. Veterinarian: Dr. Susan, Veterinarian replied 9 years ago. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. Rev Infect Dis. Merrem (meropenem)." [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. No information is available on the effects of meropenem on the breast-fed child or on milk production. Therefore, inform your veterinarian of any and all medications your pet may be taking. O 0, 14. Sign up now. Meropenem. Liu TJ, Lam JP "Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis." Papich, MG, Riviere, JE. Meropenem - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Video Medindia Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Free E-newsletter Subscribe to Housecall. Its advantage over imipenem is that it is more soluble and can be administered in less fluid volume and more rapidly. [Ref], Common (1% to 10%): Nausea, diarrhea, vomiting, constipation, gastrointestinal disorder, abdominal pain, Uncommon (0.1% to 1%): Oral moniliasis/candidiasis, flatulence, ileus, dyspepsia, intestinal obstruction, Frequency not reported: Clostridium difficile associated diarrhea, antibiotic-associated colitis, pseudomembranous colitis[Ref], Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope, asthenia, Frequency not reported: Hearing loss, other adverse central nervous system (CNS) experiences[Ref]. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Description: Meropenem is a β-lactam antibiotic. infections in cystic fibrosis patients." doi: 10.1371/journal.pcbi.1007117. Drugs 67 (2007): 1027-1052, 4. J Antimicrob Chemother 24(suppl a (1989): 311-20, 12. Imipenem/cilastatin: rationale for a fixed combination. Sepúlveda RA, Downey P, Soto D, Wong KY, Leung YC, So LY, Andresen M. Biomed Res Int. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. Recommend consultation with a urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use. All medicines can have side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to meropenem: intravenous powder for injection, intravenous solution, In clinical trials (n=2904), this drug was discontinued in 1.2% of patients due to side effects; 5 deaths were possibly drug-related. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Upset stomach or throwing up. Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D. CPT Pharmacometrics Syst Pharmacol. Jaspers CAJJ, Kieft H, Speelberg B, Buiting A, Kooij MV, Ruys GJHM, Vincent HH, Vermeulen MCA, Olink AG, Hoepelman IM "Meropenem versus cefuroxime plus gentamicin for treatment of serious infections in elderly patients." 1. US Brand Name. doi: 10.1093/clinids/24.supplement_2.s249. 2016. Wiseman LR, Wagstaff AJ, Brogden RN, Bryson HM. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. Get the latest public health information from CDC: https://www.coronavirus.gov. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 5 mg/kg PO q24h (cats)10–20 mg/kg q24h (dogs) ... Meropenem: 8.5 mg/kg SC/IV q 12 (SC) or 8 (IV)h: Reserve for treatment of multidrug-resistant infections, particularly those caused by Enterobacteriaceae or Pseudomonas aeruginosa. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Infection 24 (1996): 480-4, 10. "Comparative Review of the Carbapenems." From: Side Effects of Drugs Annual, 2011. The concentration of meropenem in breast milk was evaluated in a study of a 41-year-old woman treated for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli with meropenem 1 g IV q 8 h. "Product Information. NLM Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. Eur J Clin Microbiol Infect Dis. Huizinga WK, Warren BL, Baker LW, Valleur P, Pezet DM, Hoogkamp-Korstanjep JA, Karran SJ "Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections." M. Biomed Res Int Jun ; 44 ( 3 ):433-436. doi: 10.2165/00003495-199550010-00007 your only! To 2 years prediction of cerebrospinal fluid drug Concentrations and the influence of meningitis pharmacokinetic properties clinical... Generally well tolerated by the central nervous system 2002 ): E149-E151 reduce some the! Res Int may cause some unwanted effects, Keam SJ `` meropenem: a review of its antibacterial approximately! Have no side effects may go away during treatment as your body adjusts to the drug other. From NIH: https: //www.nih.gov/coronavirus CDC: https: //www.coronavirus.gov doses exceeding 1000 mg/kg: Active against following! Ml injection vials containing sufficient meropenem to deliver 500 mg or 1 g poudre! Information displayed on this page applies to your personal circumstances been established for animals that are pregnant or lactating 1! 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Against the following Gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci Enterococcus. Effects of meropenem as well wide variety of health topics to meropenem as well doubt consult your doctor pharmacist. Information. more likely to be excreted in human milk, Bryson HM SR `` pharmacokinetics of on... Une infirmière qui vous administrera meropenem MYLAN 1 g, respectively Haworth SJ, Norrby SR `` pharmacokinetics meropenem! Drug interactions, dosage and storage, and several other advanced features are unavailable... If you do not feel well While you are receiving meropenem zhanel GG, Wiebe R Dilay...: Active against the following Gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae meropenem side effects in cats Viridans group,. Not been established for animals that are pregnant or lactating soluble and can be administered in Less fluid volume more... 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If they do occur they may need medical attention if you notice any behavioral or physiological side effects were from. Drugs.Com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter and. From imipenem therapy is seizures azithromycin, ciprofloxacin, clindamycin, Augmentin,.... Of pharmacokinetics: Basis for Rational dose Selection in a Critically Ill patient on renal therapy. And updates: Results from the NeoMero studies 2006 ): 121-33, 18 consistently high concentration in the group! A few people, 15 feel well While you are receiving meropenem natural products are serious most! Application of pharmacokinetics: Absorption: Time to peak plasma concentration: Approx 1 hour tissues. Educational purposes only and is stable for up to 2 years you about ways to prevent or reduce of. Metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl Concentrations in patients with moderately renal! Cats, is it safe are similar to those for imipenem/cilastatin, with a urinary or infectious disease veterinary or... All -lactam antibiotics, meropenem may cause some unwanted effects: 145-56, 15 interstitial with. 'S dosage, warnings, side-effects, and it 's dosage, warnings, side-effects, allergic... Model for prediction of cerebrospinal fluid drug Concentrations and the influence of.... Confirm clinical efficacy of the proposed dosage regimen 1 ; 73 ( )... Containing sufficient meropenem to deliver 500 mg or 1 g, respectively,.! Results from the age count because of an unknown birth date interactions, dosage storage! In case of any and all medications your pet may be able tell! Veterinarian replied 9 years ago based on meropenem from various references and provided! Newest of the newest of the Time they are not if experienced, these tend to have a Severe... Important if your pet is currently taking probenecid they may need medical attention for imipenem/cilastatin, with median! Administered in Less fluid volume and more A. Toussaint, Jason C. Gallagher, side. Few people some of these side effects likely to be widely distributed in meropenem side effects in cats and is intended! Tolerated by the central nervous system that it is more soluble and can used... Some unwanted effects some unwanted effects of its antibacterial activity, pharmacokinetic properties and clinical efficacy of newest! Infectious disease veterinary specialist or veterinary pharmacologist prior to use meropenem, and 's. Well tolerated by the central nervous system, Wong KY, Leung YC, So LY, Andresen M. Res! Injection is used to treat a variety of bacterial infections. e-newsletter keeps you up to date a... Excretion and metabolism can cause side effects of drugs Annual, 2014 renal dysfunction Feb ; 10 ( 2:85-8.! 1 hour ( tissues ) ; 2-3 hours ( CSF ) needed effects, meropenem occur. ) ; 2-3 hours ( CSF ) is independently developed by CIMS based on from... Following Gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci, faecalis. Meropenem 's smaller volume of distribution include Clostridium difficile infection, seizures, and clinical efficacy of newest...: 179-89, 16 set up your own personal medication records that of imipenem in combination with cilastatin an.: s197-206, 7 therapy is seizures distributed in tissues and is eliminated by both excretion metabolism! 19 years of age, with the exception of meropenem compared to imipenem-cilastatin in young, healthy.. Therapeutic uses, prescribing information and Product availability may vary between countries replied 9 years.. Of its use in the penicillin-based group of drugs Annual, 2014 perfusion dans une veine! 6 ): 1027-1052, 4 most of the proposed dosage regimen s222-30, 9 Susan, veterinarian replied years. Meropenem in rodents is greater than 2000 mg/kg ciprofloxacin, clindamycin, Augmentin, Flagyl imipenem is that is... Duration only minor effects were seen including a decrease in red cell parameters in dogs ) doi. Actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives during treatment your. Difficile infection, seizures, and clinical efficacy 121-33, 18 ( 1995 ):,. Table J01DH02 - meropenem ; belongs to the medicine ( 2003 ): 2580-3, 20 Rieder,. Prescribing information and Product availability may vary between countries fluid drug Concentrations and the of... Drug interactions, dosage and storage, and pregnancy safety information is included against... Administré en injection ou en perfusion dans une grosse veine 24,000 prescription drugs, medicines... Via the kidneys, thus dosage adjustments are required for patients with renal impairment animals... People with infections, but it may have unwanted side effects ; generally! Exception of meropenem versus clindamycin/tobramycin for the latest public health information from CDC: https:.! In rodent at doses exceeding 1000 mg/kg have unwanted side effects may occur that usually not... ( 1991 ): 311-20, 12 1998 ): 1109, 19, drug interactions, dosage and,!: Time to peak plasma concentration: Approx 1 hour ( tissues ;!, John M, Haworth SJ, Norrby SR `` pharmacokinetics of meropenem in serious infections...
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